This can cause your cup of coffee to stop giving you that energy boost you’re used to. When you lack sleep, adenosine reverses the effects. And, when you drink coffee, the caffeine binds to those particles, helping you stay awake. You’ll be surprised to see that drinking a cup of coffee wouldn’t affect you like it normally would.Ī possible explanation is that when you feel sleepy, your body produces adenosine. If you don’t get enough sleep for one night, it doesn’t mean that caffeine won’t affect you.īut, don’t sleep for at least three nights and see what happens. Over time, you can reset your body’s adenosine receptors and start experiencing the effects of caffeine once again. To counteract this, try slowly limiting your caffeine intake. If you’re one of those who consume more caffeinated drinks than usual, you might observe that you can still sleep well even after drinking a cup. You won’t feel the kick you need to stay awake or get through your day. Once your body develops tolerance to caffeine, it manufactures more adenosine receptors since the existing receptors already have caffeine bound to them. You’ve Developed Caffeine ToleranceĬaffeine tolerance happens when you drink coffee too frequently. If you’re unfortunate, you might have the variant that metabolizes caffeine faster.įaster caffeine metabolism means fewer effects of your morning cup of coffee on your body. The primary liver enzyme responsible for caffeine metabolism is CYP1A2, and it has two variants. They dictate how fast your body breaks down caffeine and how long it stays in your system. When caffeine can’t bind to these receptors, it won’t be able to block sleepiness and boost your energy.Īside from adenosine receptors, liver enzymes also play a critical role. If you belong to the 10%, you may not have “sticky” adenosine receptors, causing caffeine to have difficulty binding to them. A 2011 study revealed that about 10% of people possess a gene that makes them immune to the effects of caffeine. One of the most common reasons why coffee may not affect you is due to genetics. Let’s take a look at a few reasons why coffee might not have the energy-enhancing effects that it’s famous for! It’s Hereditary Well, there are several reasons why coffee does not have the same effect on you as it does on other people. If you’re part of the second group of people, you might ask yourself, “why does coffee not affect me?”. However, there’s also a group of people who don’t feel any sort of caffeine kick after drinking. For most people, drinking coffee boosts their energy, helping them get through the day.
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